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Clinicaltrials.gov was searched for registered examine protocols. The keywords and phrases “palmitoylethanolamide” and “ache” resulted in thirteen entries, of which three had been accomplished. None of them fulfilled our eligibility criteria.The clinical reports investigated in detail while in the present review are of variable good quality

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Central administration of palmitoylethanolamide reduces hyperalgesia in mice by way of inhibition of NF??B nuclear signalling in dorsal root ganglia. Eur J PharmacolThis can be of significance with regard for the catabolism of exogenous PEA if fatty acid binding proteins Perform a predominant purpose in its intracellular transportation following it

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